Difference between revisions of "Phosphatase Subfamily PPM1K"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP) | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP) | ||
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| + | PPM1K is a mitochondrial phosphatase that regulates the membrane permeability transition pore and is part of the BCKDA complex. | ||
=== Evolution === | === Evolution === | ||
Revision as of 00:39, 4 March 2017
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1K (PP2Cκ, PP2Cm, BDP)
PPM1K is a mitochondrial phosphatase that regulates the membrane permeability transition pore and is part of the BCKDA complex.
Evolution
The PPM1K subfamily emerged in holozoa. It was lost in ecdysozoa and sponge. PPM1K is most similar to the ER-anchored phosphatase subfamily PPM1L.
Domain
The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain [1, 2]. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily.
Functions
Human PPM1K is widely expressed in different tissues, most abundant in heart [1, 2] and GTEx database. Human PPM1K is localized to mitochondrial matrix [2]. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear [2]. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex [1].
References
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