Phosphatase Subfamily CDC25

Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25

Evolution

CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in some if not many genomes. For example, human, fruit fly and C elegans have 3, 2, 4, respectively, and they do not fall into 1:1 orthologous relationship.

Domain

Human CDC25s have an N-terminal regulatory domain and phosphatase domain, called M-phase inducer phosphatase domain in Pfam. Due to alternative splicing, the isoforms of human CDC25s have different sequences at regulatory domain region. The N-terminal regulatory domain is found in most deuterostomes, but not protostomes.

Catalytic activity and functions

Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Their structures and functions have been reviewed in detail [1, 2, 3].

References

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