Phosphatase Subfamily PPM1Z

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1Z

Evolution

The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to PPM1G, but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to PPM1A, and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies.

Notice: Monosiga has an unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z.

Domain

The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.

Functions

The function of PPM1Z is unclear.