Phosphatase Subfamily Dullard

Phosphatase Classification: FCP:Subfamily Dullard

Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human [1] (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.

Evolution

Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the described kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals.

Substrates and Related Kinases

	Phosphatase	Lipin	Kinase
Yeast	Nem1-Spo7 complex	Smp2	Cdc28/Cdk1
Mammals	Dullard (-? complex)	LIPIN	mTOR

Notes:

1. Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 [2].

2. mTOR (in mammals). Lipin has multiple phosphorylation sites. Though many kinases may involve in the multisite phosphorylation, mTOR plays an important role [3].

References

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Links

Human Dullard from NCBI Gene