Phosphatase Family LMWPTP

Phosphatase Classification: Superfamily Cys-based III: Family LMWPTP

Function

In eukaryotes, LMWPTP dephosphorylates many receptor tyrosine kinases, such as platelet-derived growth factor receptor (PDGFR), insulin receptor (InsR), or ephrin receptor (Eph) [1].

In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.

Evolution

The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.

Reference

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