Phosphatase Subfamily PPM1Z

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1Z

Evolution

The PPM1Z subfamily is found in fungi and animals but lost from jawed vertebrates, sponge, and some fungi. Its sequence is most similar to PPM1G, but it lacks the acidic domain inserted into phosphatase domain which is a characteristic of PPM1G.

The subfamily belongs to the same gene cluster with PPM1A subfamily in our internal orthology database based on OrthoMCL algorithm. Inferring the evolutionary history by comparing the sequences of the gene cluster, the subfamily is mostly like to emerge in metazoa or holozoa through the duplication of the common ancestral gene of this subfamily and PPM1A subfamily.

Notice: Monosiga has an unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z.

Domain

The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.

Functions

The function of PPM1Z is unclear.