Phosphatase Subfamily YNL217W

Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPP: Subfamily YNL217W

The subfamily is named after budding yeast YNL217W.

Evolution

The YNL217W subfamily is found in fungi and scattered metazoa, including sponge, molluscs, sea urchin, lancet, and ciona but is not present in any vertebrate, or in insects or nematodes. Related genes are also found in algae, but not higher plants, and an array of other basal or poorly-classified eukaryotes, and is similar to phosphatases found in several bacteria. This group has overlaps with the "Alphs" group of phosphatases previously described [1]

Domain

The YNL217W subfamily has a single known structural domain, PPPc domain.

Functions

The function is unknown. The yeast protein localizes to the vacuole, and the mutation shows a mild defect in vacuolar fragmentation [2].

This family is closest in sequence to bacterial diadenosine tetraphosphatases (adaH, prpA) that hydrolyze diadenosine tetraphosphate to yield ADP [3].

References

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