Phosphatase Subfamily TIMM50

Phosphatase Classification: FCP: TIMM50

TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.

Evolution

TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human.

Catalytic activity

None

Related Kinases

1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [3], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).

References

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Links

Human TIMM50 from NCBI Gene