Phosphatase Family CDC25

Phosphatase Classification: Superfamily CC3 (Rhondanese): Family CDC25

CDC25 is the only CC2 superfamily family with protein phosphatase activity. It consists of two subfamilies, CDC25 and Acr2. CDC25 is is an important phosphatase of cyclin-dependent kinases (CDKs), the function role of Acr2 is controversial.

CDC25 and Acr2 are found in a mostly mutually exclusive manner across eukaryotes. CDC25 is found in most animals, but is absent from land plants and green alga Chlamydomonas. On the other hand, Acr2 is found in most plants and Chalmydomonas, but is absent from animals and green alga Ostreococcus. However, in fungi and amoebozoans, both CDC25 and Acr2 are present.