Phosphatase Subfamily CDC25
Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25
Evolution
CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in many species, including two in human, and Drosophila and four in C. elegans, all from apparently independent duplications.
Domain
Human CDC25s have an N-terminal regulatory domain and phosphatase domain, called M-phase inducer phosphatase domain in Pfam. Due to alternative splicing, the isoforms of human CDC25s have different sequences at regulatory domain region. The N-terminal regulatory domain is found in most deuterostomes, but not protostomes.
Catalytic activity and functions
Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Their structures and functions have been reviewed in detail [1, 2, 3].
References
- Boutros R, Dozier C, and Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol. 2006 Apr;18(2):185-91. DOI:10.1016/j.ceb.2006.02.003 |
- Rudolph J. Cdc25 phosphatases: structure, specificity, and mechanism. Biochemistry. 2007 Mar 27;46(12):3595-604. DOI:10.1021/bi700026j |
- Boutros R, Lobjois V, and Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat Rev Cancer. 2007 Jul;7(7):495-507. DOI:10.1038/nrc2169 |
