Phosphatase Gene HsapP726

TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element.

Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation [1].

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