Phosphatase Subfamily PP2D1

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PP2D1

Evolution

The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and the zebrafish.

Domain

The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using NLS mapper and NLStradamus.

Function

The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta [1]

References

1. Virok DP, Simon D, Bozsó Z, Rajkó R, Datki Z, Bálint É, Szegedi V, Janáky T, Penke B, and Fülöp L. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. J Proteome Res. 2011 Apr 1;10(4):1538-47. DOI:10.1021/pr1009096 |