Human Protein Phosphatase Pseudogene

Functions

Almost all of the pseudogenes are functional unknown, but they may have certain functions. The best example is PTENP1, which is a processed pseudogene of PTEN and regulates PTEN by both sense and antisense RNAs. DUSP5P1 may be also functional, as implicated by that it is highly expressed in Hodgkin's lymphoma cell line L-1236 but not in normal blood cells or Epstein-Barr virus-immortalized B cells. Besides, there are putative disease-related SNPs within or adjacent to the regions of the pseudogenes, as found by genome-wide association studies (GWAS).

List of pseudogenes

The notes are last updated on 10/08/2015.

PGAM1Ps
- PGAM1P1
- PGAM1P10
- PGAM1P11
- PGAM1P12
- PGAM1P13
- PGAM1P14
- PGAM1P2
- PGAM1P3
- PGAM1P4
- PGAM1P5
- PGAM1P6
- PGAM1P7
- PGAM1P8
- PGAM1P9

TPTE2Ps
- LOC400927
- TPTE2P1
- TPTE2P2
- TPTE2P3
- TPTE2P4
- TPTE2P5
- TPTE2P6
- TPTE2P7
- TPTE2P8

SSU72Ps
- SSU72P1
- SSU72P2
- SSU72P3
- SSU72P4
- SSU72P5
- SSU72P6
- SSU72P7
- SSU72P8

PTP4A1Ps (PRL1 pseudogenes)
- PTP4A1P1
- PTP4A1P3
- PTP4A1P4
- PTP4A1P5
- PTP4A1P6
- PTP4A1P7

DUSP8Ps
- DUSP8P1
- DUSP8P2
- DUSP8P3
- DUSP8P4
- DUSP8P5

PTP4A2Ps (PRL2 pseudogenes)

PTPN11Ps (SHP-2 pseudogenes): none of the three is included in Entrez database.

DULLARD pseudogenes
- CTDNEP1P1
- CTDNEP1P2

PGAM4Ps
- PGAM4P1
- PGAM4P2

MTMR5/SBF1 pseudogenes
- SBF1P1
- SBF1P2

CDC14
- CDC14C: emerged through retroposition in the hominoid ancestor 18-25 million years ago
- CDC14BL: originates from pseudogene CDC14C

DUSP5Ps
- DUSP5P1: highly expressed in Hodgkin's lymphoma cell line L-1236 but not in normal blood cells or Epstein-Barr virus-immortalized B cells
- DUSP5P2