Difference between revisions of "Phosphatase Family HP1"
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======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3) ====== | ======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3) ====== | ||
− | STS is protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in | + | STS is a protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoa. |
======[[Phosphatase_Subfamily_PFKFB|PFKFB]]====== | ======[[Phosphatase_Subfamily_PFKFB|PFKFB]]====== |
Revision as of 20:55, 7 April 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family
Subfamilies found in human
PGAM
PGAMs mainly function as glycolytic enzymes regulating intracellular levels of their substrate 3-phosphoglycerate and product 2-phosphoglycerate. Human BPGM is a 2,3-bisphosphoglycerate mutase. They are found throughout most eukaryotes.
PGAM5
PGAM5 is a protein phosphatase conserved in metazoan. It has distinct substrates.
TIGAR
Vertebrate TIGAR functions as a fructose-2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.
STS (TULA or UBASH3)
STS is a protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoa.
PFKFB
PFKFB is a bifunctional enzyme responsible for the synthesis (as kinase) and degradation (as phosphatase) of fructose-2,6-bisphosphatase that is a signal molecule that controls glycolysis. Its two opposite enzymatic activities are encoded in two separate domains, N-terminal kinase domain and C-terminal phosphatase domain. PFKFB is found in most if not all eukaryotes. It emerged by gene fusion of the ancestors of the gene containing kinase domain and that containing phosphatase domain.
Other subfamilies
Cele-STS-like
Nematode-specific subfamily has a phosphatase domain of HP1 family. It is close to STS subfamily, but lacks UBA and SH3 domains.
TFC7
TFC7 is a RNA pol III transcription initiation factor complex (TFIIIC) subunit found in fungi and Dictyostelium.
HP1LE
HP1LE subfamily is found in choanoflagellates and sponge, but is absent from eumetazoan. Its function is unclear.