Phosphatase Gene HsapP726

TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element.

Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation [1]. A 15 kD ORF was detected by peptide antibodies.

References

1. Liang Q, Ding J, Xu R, Xu Z, and Zheng S. The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer. 2010 Oct 15;127(8):1833-43. DOI:10.1002/ijc.25213 |