Phosphatase Subfamily CelePPP-sf4

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Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPP: Subfamily CelePPP-sf4

This is a nematodes-specific subfamily of PPP phosphatases, implicated in spermatogenesis


CelePPP-sf4 is found in nematodes, with 10 members in C. elegans.


The CelePPP-sf4 subfamily has a single known structural domain, PPP domain. One member (C09H5.7) has a weak signal peptide, but it is not conserved and may be a false positive.


Two members, gsp-3 and gsp-4 have been characterized as important for spermatogesis in C. elegans [1]. They are required for chromosome partitioning in meiosis and for sperm motility. Nematodes lack flagellae and centrosomes, and use a pseudopod-based motility, suggesting that this may be part of this nematode-specific apparatus. gsp-3/4 can also interact with MEMI proteins that are involved in female meiosis, post-fertilization [2].

A member from Haemonchus contortus is expressed only in males [3].


  1. Wu JC, Go AC, Samson M, Cintra T, Mirsoian S, Wu TF, Jow MM, Routman EJ, and Chu DS. Sperm development and motility are regulated by PP1 phosphatases in Caenorhabditis elegans. Genetics. 2012 Jan;190(1):143-57. DOI:10.1534/genetics.111.135376 | PubMed ID:22042574 | HubMed [Wu]
  2. Ataeian M, Tegha-Dunghu J, Curtis DG, Sykes EM, Nozohourmehrabad A, Bajaj M, Cheung K, and Srayko M. Maternal MEMI Promotes Female Meiosis II in Response to Fertilization in Caenorhabditis elegans. Genetics. 2016 Dec;204(4):1461-1477. DOI:10.1534/genetics.116.192997 | PubMed ID:27729423 | HubMed [Ataeian]
  3. Campbell BE, Rabelo EM, Hofmann A, Hu M, and Gasser RB. Characterization of a Caenorhabditis elegans glc seven-like phosphatase (gsp) orthologue from Haemonchus contortus (Nematoda). Mol Cell Probes. 2010 Aug;24(4):178-89. DOI:10.1016/j.mcp.2010.02.001 | PubMed ID:20153820 | HubMed [Campbell]
All Medline abstracts: PubMed | HubMed