Difference between revisions of "Phosphatase Subfamily PP2D1"

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(Evolution)
 
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=== Evolution  ===
 
=== Evolution  ===
The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and the zebrafish.
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The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48).
  
 
=== Domain ===
 
=== Domain ===
The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using [http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi NLS mapper] and [http://www.moseslab.csb.utoronto.ca/NLStradamus/ NLStradamus].
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The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using [http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi NLS mapper] and [http://www.moseslab.csb.utoronto.ca/NLStradamus/ NLStradamus]. [http://www.proteinatlas.org/search/PP2D1 Protein Atlas] reports it to be found in the nucleoplasm and intermediate filaments, by high-throughput antibody staining.
  
 
=== Function ===
 
=== Function ===
Human PP2D1 is predicted to be localized to the nucleus.
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The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta <cite>Virok</cite>
  
 
=== References ===
 
=== References ===
 
<biblio>
 
<biblio>
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#Virok pmid=21244100
 
</biblio>
 
</biblio>

Latest revision as of 21:37, 4 March 2017

Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PP2D1

Evolution

The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48).

Domain

The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using NLS mapper and NLStradamus. Protein Atlas reports it to be found in the nucleoplasm and intermediate filaments, by high-throughput antibody staining.

Function

The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta [1]

References

  1. Virok DP, Simon D, Bozsó Z, Rajkó R, Datki Z, Bálint É, Szegedi V, Janáky T, Penke B, and Fülöp L. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. J Proteome Res. 2011 Apr 1;10(4):1538-47. DOI:10.1021/pr1009096 | PubMed ID:21244100 | HubMed [Virok]