Phosphatase Subfamily PP2D1

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Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PP2D1


The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48).


The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using NLS mapper and NLStradamus. Protein Atlas reports it to be found in the nucleoplasm and intermediate filaments, by high-throughput antibody staining.


The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta [1]


  1. Virok DP, Simon D, Bozsó Z, Rajkó R, Datki Z, Bálint É, Szegedi V, Janáky T, Penke B, and Fülöp L. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. J Proteome Res. 2011 Apr 1;10(4):1538-47. DOI:10.1021/pr1009096 | PubMed ID:21244100 | HubMed [Virok]