Accesory Domain Gains and Losses

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Below is the list of protein phosphatase subfamilies which has gained and/or lost accessory domains. The loss of a domain can be categorized into two types: 1) a complete loss of the domain which means no sequence at the region where the domain is supposed to be at; 2) the sequence is too divergent to be considered as the domain.

  • ACP5
  • CDC25. Caenorhabditis lost the regulatory N-terminal domain (CDC25_NTD). The insect CDC25s has a CDC25_NTD domain, but is quite divergent from other eumetazoa CDC25s.
  • Tensin.