Other Classification Schemes

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Phosphatase Classification: Other Classification Schemes

PPP (PP1, PP2A, PP2B) and PPM (PP2C)

Using enzymological criteria, PPP & PPM members were initially classified as type 1 (PP1) and type 2 (PP2). PP2 enzymes were further divided into three groups on the basis of the requirement for metal ions: PP2A (not requiring metal ions), PP2B (requiring calcium), and PP2C (requiring magnesium). Based upon their sequence and structure similarity, PP1, PP2A and PP2B form PPP, and PP2C forms PPM.