Phosphatase Family ArsC

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Phosphatase Classification: Superfamily CC2: Family ArsC

Arsenate reductase (ArsC) [1], is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity.

Eukaryotes (particularly fungi, plants and protists) have different arsenate reductase, Acr2 of CC3 superfamily [2].


  1. Bennett MS, Guan Z, Laurberg M, and Su XD. Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13577-82. DOI:10.1073/pnas.241397198 | PubMed ID:11698660 | HubMed [Bennett]
  2. Yeo HK and Lee JY. Crystal structure of Saccharomyces cerevisiae Ygr203w, a homolog of single-domain rhodanese and Cdc25 phosphatase catalytic domain. Proteins. 2009 Aug 1;76(2):520-4. DOI:10.1002/prot.22420 | PubMed ID:19382206 | HubMed [yeo09]
All Medline abstracts: PubMed | HubMed