Phosphatase Family MDP1
From PhosphataseWiki
Phosphatase Classification: Superfamily HAD: Family MDP1
This family typically has one member in unikonts (MDP1 in human), though it is lost from Drosophila and C. elegans. It has been reported as a putative tyrosine phosphatase [1]. However, a later study reported that it is a protein-fructosamine-6-phosphatase potentially involved in glycation repair [2]. This activity was 100-fold higher than its tyrosine phosphatase activity, and MDP1 has not been shown to have activity on phosphopeptides [3].
References
- Peisach E, Selengut JD, Dunaway-Mariano D, and Allen KN. X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry. 2004 Oct 12;43(40):12770-9. DOI:10.1021/bi0490688 |
- Fortpied J, Maliekal P, Vertommen D, and Van Schaftingen E. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. J Biol Chem. 2006 Jul 7;281(27):18378-85. DOI:10.1074/jbc.M513208200 |
- Selengut JD and Levine RL. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Biochemistry. 2000 Jul 18;39(28):8315-24. DOI:10.1021/bi0005052 |
