Phosphatase Subfamily CTDSPL2

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Phosphatase Classification: FCP: CTDSPL2

CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.


CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called HSPC058, HSPC129, or SCP4

Domain Structure

Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension

Catalytic activity

Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.


Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.


  1. Qian H, Ji C, Zhao S, Chen J, Jiang M, Zhang Y, Yan M, Zheng D, Sun Y, Xie Y, and Mao Y. Expression and characterization of HSPC129, a RNA polymerase II C-terminal domain phosphatase. Mol Cell Biochem. 2007 Sep;303(1-2):183-8. DOI:10.1007/s11010-007-9472-z | PubMed ID:17487459 | HubMed [qian]
  2. Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, and Lin X. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26441-26450. DOI:10.1074/jbc.M114.568964 | PubMed ID:25100727 | HubMed [Zhao]
All Medline abstracts: PubMed | HubMed


Human CTDSPL2 from NCBI Gene