Phosphatase Subfamily PPP7C

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Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPP: Subfamily PPP7C

Note: the page is under construction.


The PPP7C subfamily is found in eumetazoa and Placozoa Trichoplax adhaerens, but it is not present in sponge.


PPP7Cs typically have a domain combination of IQ calmodulin-binding motif, TPR structural motif mediating protein-protein interaction, PPP phosphatase domain, and tandem EF hand structural motifs binding to calcium. The domain combination makes it easier and more confident to identify PPP7Cs. Drosophila melanogaster PPP7C, rdgC, has two TPR motifs.


Human has two members in PPP7C subfamily, PPEF1 (PPP7CA) and PPEF2 (PPP7CB).


PPEF-1 interacts with and dephosphorylates Programmed cell death 5 (PDCD5) at Ser-119, which leads to PDCD5 destabilization. It is believed to play a crucial role in p53 activation [1].


  1. Park SY, Seo J, Choi HK, Oh HJ, Guk G, Lee YH, Lee J, Jun WJ, Choi KC, and Yoon HG. Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5. Sci Rep. 2017 Jan 4;7:39222. DOI:10.1038/srep39222 | PubMed ID:28051100 | HubMed [Park2017]