Phosphatase Subfamily UBLCP1
UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain .
It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.
It has a different catalytic motif from other subfamilies of FCP.
- Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 |
Human UBLCP1 from NCBI Gene