Phosphatase Subfamily UBLCP1

From PhosphataseWiki
Jump to: navigation, search

Phosphatase Classification: FCP: Subfamily UBLCP1


UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain [1].

Evolution

It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.

Domain Structure

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

Catalytic activity

It has a different catalytic motif from other subfamilies of FCP.

Curation notes

References

  1. Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 | PubMed ID:15883030 | HubMed [clone]


Links

Human UBLCP1 from NCBI Gene