Phosphatase Subfamily UBLCP1

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Phosphatase Classification: FCP: Subfamily UBLCP1

UBLCP1 is named after Ubiquitin-like domain containing CTD phosphatase 1. It has an accessary N-terminal domain, similar to ubiquitin. Its function is not well characterized, though in vitro assay showed phosphatase activity toward RNA polymerase II C-terminal domain [1].


It is conserved from Nematostella to human but lost in nematode. However, UBLCP1-like proteins can be found in plants.

Domain Structure

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

Catalytic activity

It has a different catalytic motif from other subfamilies of FCP.

Curation notes


  1. Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, and Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. DOI:10.1016/j.bbrc.2005.04.065 | PubMed ID:15883030 | HubMed [clone]


Human UBLCP1 from NCBI Gene