View source for Phosphatase Subfamily MTMR9

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_MTMR9|Subfamily MTMR9]]

MTMR9 is a conserved pseudophosphatase across holozoan. It regulates active phosphatases of subfamily MTMR6.

===Evolution===
MTMR9 is found throughout holozoan. It is usually single copy per genome.

===Domain Structure===
MTMR9 subfamily has three domains: [http://pfam.xfam.org/family/PF02893.15 PH/GRAM], phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins. As shown in [[Phosphatase_Subfamily_MTMR3|MTMR3 subfamily]], PH/GRAM domain can bind to phosphoinositide lipids. In Monosiga, the GRAM is replaced by a C1 domain, which is also a lipid-binding domain. Coiled-coil domain has been shown to mediate the interaction between MTMR9 and members of [[Phosphatase_Subfamily_MTMR6|MTMR6]] in human <cite>Mochizuki03, zou09, zou12</cite>.

===Catalytic activity and functions===
MTMR9 is an inactive phosphatase (pseudophosphatase). MTMR9 binds to phosphatases of MTMR6 subfamilies: MTMR6 <cite>zou09</cite>, MTMR7 <cite>Mochizuki03</cite>, MTMR8 <cite>zou12</cite>. The interactions increase the enzymatic activity of these phosphatases. The interaction between MTMR9 and members of MTMR6 subfamily is also observed in C elegans <cite>marie10</cite>.

===References===
<biblio>
#Mochizuki03 pmid=12890864
#zou09 pmid=19038970
#zou12 pmid=22647598
#marie10 pmid=21076391
</biblio>