View source for Phosphatase Subfamily CUT

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[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Group_HAD|HAD]]: [[Phosphatase_Family_NagD|NagD]]:  [[Phosphatase_Subfamily_Cut|Cut]]

Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.

== Evolution ==
This family is present throughout eukaryotes (while it is absent from fruit fly, it is found in other arthropods). It has a single copy in mammals, 2 copies in chicken (but single copy in turkey), 2-3 copies in fishes, 2-3 copies in fungi, 2-3 copies Discicristates, and even 6 copies in Tetrahymena. Phylogenetic tree shows these copies are due to different duplication events. 

== Notes ==
Various Cut genes have been localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).

== References ==
<biblio>
#Barbe pmid=18029348
#Reinders pmid=16823961
#Richter pmid=20186120
#Youssar pmid=16807008
</biblio>