Phosphatase Subfamily CUT

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Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily CUT

Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.


This family is present throughout eukaryotes, mostly single-copy but with several duplications [1]. It is lost from Drosophila but present in other arthropods.


CUT has a single domain, HAD domain.


Cut proteins are localized to the mitochondria [2, 3]. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase [4] and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress [5]. A PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (, p129).


  1. Chen MJ, Dixon JE, and Manning G. Genomics and evolution of protein phosphatases. Sci Signal. 2017 Apr 11;10(474). DOI:10.1126/scisignal.aag1796 | PubMed ID:28400531 | HubMed [Chen]
  2. Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, and Andersson-Svahn H. Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics. 2008 Mar;7(3):499-508. DOI:10.1074/mcp.M700325-MCP200 | PubMed ID:18029348 | HubMed [Barbe]
  3. Reinders J, Zahedi RP, Pfanner N, Meisinger C, and Sickmann A. Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res. 2006 Jul;5(7):1543-54. DOI:10.1021/pr050477f | PubMed ID:16823961 | HubMed [Reinders]
  4. Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, and Chrzanowska-Lightowlers ZM. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. EMBO J. 2010 Mar 17;29(6):1116-25. DOI:10.1038/emboj.2010.14 | PubMed ID:20186120 | HubMed [Richter]
  5. Youssar L and Avalos J. Light-dependent regulation of the gene cut-1 of Neurospora, involved in the osmotic stress response. Fungal Genet Biol. 2006 Nov;43(11):752-63. DOI:10.1016/j.fgb.2006.05.003 | PubMed ID:16807008 | HubMed [Youssar]
All Medline abstracts: PubMed | HubMed