Phosphatase Superfamily HAD

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Phosphatase Classification: Fold HAD: Superfamily HAD


The HAD (HaloAcid Dehalogenase) superfamily contains many different hydrolase enzymes, including three with reported protein phosphatase activity [1, 2]:

Note: The MDP1 family has been removed from the protein phosphatome, because it has been confirmed as a protein-fructosamine-6-phosphatase.

Unclassifed HADs

  • Yeast SER2 is a putative protein serine phosphatase [3]. It does not belong to any family above.


  1. Koonin EV and Tatusov RL. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol. 1994 Nov 18;244(1):125-32. DOI:10.1006/jmbi.1994.1711 | PubMed ID:7966317 | HubMed [Koonin]
  2. Burroughs AM, Allen KN, Dunaway-Mariano D, and Aravind L. Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol. 2006 Sep 1;361(5):1003-34. DOI:10.1016/j.jmb.2006.06.049 | PubMed ID:16889794 | HubMed [Burroughs]
  3. Kuznetsova E, Nocek B, Brown G, Makarova KS, Flick R, Wolf YI, Khusnutdinova A, Evdokimova E, Jin K, Tan K, Hanson AD, Hasnain G, Zallot R, de Crécy-Lagard V, Babu M, Savchenko A, Joachimiak A, Edwards AM, Koonin EV, and Yakunin AF. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. J Biol Chem. 2015 Jul 24;290(30):18678-98. DOI:10.1074/jbc.M115.657916 | PubMed ID:26071590 | HubMed [Kuznetsova15]
All Medline abstracts: PubMed | HubMed