Phosphatase Family NagD
The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:
- PGP is ubiquitous in eukaryotes. The two members in human have distinct functions: PGP is a putative tyrosine-specific protein phosphatase, and PDXP (chronophin) dephosphorylates cofilin on serine, and also dephosphorylates pyridoxal 5'-phosphate. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.
- LHPP is a protein histidine phosphatase subfamily conserved in holozoa.
- CUT is a mitochondrial-associated probable non-protein phosphatase.