View source for Phosphatase Family SSU72

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC2|Superfamily CC2]]: [[Phosphatase_Family_SSU72|Family SSU72]]

SSU72 is a nearly pan-eukaryotic phosphatase of the RNA polymerase C-terminal domain.

===Evolution===
SSU72 is found in most eukaryotes, but is lost in most excavates and some chromalveolates. It is usually present in one copy, but humans also have 8 SSU72 retrogenes of unknown function.

===Domain Architecture===
SSU72 consist of just a phosphatase domain, with no N- or C-terminal extensions.

===Function===
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing <cite>Krish04</cite> <cite>Xiang10</cite>.

===Reference ===
<biblio>
#Krish04 pmid=15125841
#Xiang10 pmid=20861839
</biblio>