Difference between revisions of "Phosphatase Subfamily TFC7"

Revision as of 18:10, 4 January 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family: TFC7

TFC7 subfamily is found in both fungi and Dictyostellium. Budding yeast has two copies due to duplication, including TFC7 and YNL108C.

TFC7 is a RNA pol III transcription initiation factor complex (TFIIIC) subunit [1, 2]. In contrast, YNL108C may be involved in glucose metabolism (see SGD).

References

1. Manaud N, Arrebola R, Buffin-Meyer B, Lefebvre O, Voss H, Riva M, Conesa C, and Sentenac A. A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95. Mol Cell Biol. 1998 Jun;18(6):3191-200. DOI:10.1128/MCB.18.6.3191 | PubMed ID:9584160 | HubMed [manaud98]
2. Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grötsch H, Fernández-Tornero C, Rybin V, Gavin AC, Kolb P, and Müller CW. Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. J Biol Chem. 2013 May 24;288(21):15110-20. DOI:10.1074/jbc.M112.427856 | PubMed ID:23569204 | HubMed [taylor13]