Difference between revisions of "Phosphatase Subfamily PPM1Z"
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=== Evolution === | === Evolution === | ||
| − | The | + | The PPM1Z subfamily is conserved in metazoa but lost in jawed vertebrates and sponge. Its sequence is most similar to PPM1G, but it lacks the acidic domain inserted into phosphatase domain which is a character of PPM1G. |
| − | Notice: Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 a unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is | + | The subfamily belongs to the same gene cluster with [[Phosphatase_Subfamily_PPM1A|PPM1A subfamily]] in our [http://resdev.gene.com/gOrtholog/view/cluster/MC0000187/overview internal orthology database] based on [http://genome.cshlp.org/content/13/9/2178.full OrthoMCL algorithm]. Inferring the evolutionary history by comparing the sequences of the gene cluster, the subfamily is mostly like to emerge in metazoa or holozoa through the duplication of the common ancestral gene of this subfamily and [[Phosphatase_Subfamily_PPM1A|PPM1A subfamily]]. |
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| + | Notice: Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 a unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z. | ||
=== Domain === | === Domain === | ||
| − | The | + | The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily. |
=== Functions === | === Functions === | ||
| − | The | + | The function of PPM1Z is unclear. |
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=== References === | === References === | ||
<biblio> | <biblio> | ||
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</biblio> | </biblio> | ||
Revision as of 20:47, 8 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1Z
Evolution
The PPM1Z subfamily is conserved in metazoa but lost in jawed vertebrates and sponge. Its sequence is most similar to PPM1G, but it lacks the acidic domain inserted into phosphatase domain which is a character of PPM1G.
The subfamily belongs to the same gene cluster with PPM1A subfamily in our internal orthology database based on OrthoMCL algorithm. Inferring the evolutionary history by comparing the sequences of the gene cluster, the subfamily is mostly like to emerge in metazoa or holozoa through the duplication of the common ancestral gene of this subfamily and PPM1A subfamily.
Notice: Monosiga has a unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z.
Domain
The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.
Functions
The function of PPM1Z is unclear.
