Difference between revisions of "Phosphatase Gene HsapP726"

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Revision as of 17:14, 8 October 2015

Real-time quantitative RT-PCR results showed that expression of the 402-nt ORF was upregulated in normal tissues of kidney, liver, stomach, and lung but downregulated in corresponding tumor tissues. This gene is located near the centromere of chromosome 22 and has a high GC content around the promoter region. Bisulfite sequencing PCR results indicated that it is silenced in cancers by DNA methylation [1].

References

  1. Liang Q, Ding J, Xu R, Xu Z, and Zheng S. The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer. 2010 Oct 15;127(8):1833-43. DOI:10.1002/ijc.25213 | PubMed ID:20112338 | HubMed [Liang10]
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