Difference between revisions of "Phosphatases and Diseases"

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== Cancer ==
 
== Cancer ==
 +
 +
==== PTPRA ====
 +
A PTPRA splice mutant activated Src is found in human tumours <cite>Huang11</cite>.
  
 
==== [[Phosphatase_Gene_PTEN|PTEN]] ====
 
==== [[Phosphatase_Gene_PTEN|PTEN]] ====
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== References ==
 
== References ==
 
<biblio>
 
<biblio>
#Rahmouni14 pmid=24886454
 
 
#Chen15 pmid=25935522
 
#Chen15 pmid=25935522
 +
#Huang11 pmid=21725282
 +
#Rahmouni14 pmid=24886454
 
#yangj10 pmid=20562916
 
#yangj10 pmid=20562916
 
#yan14 pmid=24880341
 
#yan14 pmid=24880341
 
</biblio>
 
</biblio>

Revision as of 18:40, 15 December 2015

Cancer

PTPRA

A PTPRA splice mutant activated Src is found in human tumours [1].

PTEN

PTPN11 (SHP2)

PTPRC (CD45)

DUSP3 (VHR)

DUSP3 is a negative regulator of ERK and JNK pathways in in vitro studies in several cell lines. Though its role is involved in human cancer, its has contradictory roles since it has been alternatively described as having tumor suppressive and oncogenic properties [2].

DUSP26 (MKP8)

DUSP26 (aka MKP8) is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma [3].

PPM1D (WIP1)

PPM1D as a frequent target of somatic mutation and as a potential therapeutic target in brainstem gliomas [4].

PTPRZ1

PTPRZ1-MET (ZM) fusion protein induces gliomas through elevated expression and phosphorylation of the MET oncoprotein [5]. The fusion protein is found in human gliomas by high-throughput sequencing.

Parkinson's disease

DNAJC6

See OMIM.

Other diseases

MTMR3: Inflammatory bowel disease (IBD)

The rs713875 IBD risk polymorphism increases MTMR3 expression.

PDP1: pyruvate dehydrogenase (PDH) deficiency

See OMIM.

SBF1: Charcot-Marie-Tooth disease

See OMIM.

PPM1K: maple syrup urine disease

See OMIM.

MTMR14: centronuclear myopathy

See OMIM.

PTPRQ: deafness

See OMIM.

References

Error fetching PMID 25935522:
Error fetching PMID 21725282:
Error fetching PMID 24886454:
Error fetching PMID 20562916:
Error fetching PMID 24880341:
  1. Error fetching PMID 21725282: [Huang11]
  2. Error fetching PMID 24886454: [Rahmouni14]
  3. Error fetching PMID 20562916: [yangj10]
  4. Error fetching PMID 24880341: [yan14]
  5. Error fetching PMID 25935522: [Chen15]
All Medline abstracts: PubMed | HubMed