Difference between revisions of "Phosphatase Family Myotubularin"
| Line 5: | Line 5: | ||
== Subfamilies == | == Subfamilies == | ||
| − | === | + | ===== MTMR1 subfamily ===== |
| + | ===== MTMR3 subfamily ===== | ||
| − | === | + | ===== MTMR5 subfamily ===== |
| − | + | Inactive myotubularin subfamily. | |
| − | === | + | ===== MTMR1 subfamily ===== |
| + | ===== MTMR9 subfamily ===== | ||
| − | |||
| − | |||
| − | === | + | ===== MTMR10 subfamily ===== |
| − | === | + | ===== MTMR14 subfamily ===== |
| − | === | + | ===== C2-MTMR1 subfamily ===== |
| − | + | The feature of this subfamily is a C2 domain attached to the R1-like sequence. | |
| − | + | ||
| − | = | + | |
| + | ===== Ymr1 subfamily ===== | ||
| − | |||
== Reference == | == Reference == | ||
Revision as of 04:13, 29 May 2014
Phosphatase Classification: Superfamily Cys-based I: Myotubularin
Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. However, in C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review [1].
Contents
Subfamilies
MTMR1 subfamily
MTMR3 subfamily
MTMR5 subfamily
Inactive myotubularin subfamily.
MTMR1 subfamily
MTMR9 subfamily
MTMR10 subfamily
MTMR14 subfamily
C2-MTMR1 subfamily
The feature of this subfamily is a C2 domain attached to the R1-like sequence.
