Difference between revisions of "Phosphatases and Diseases"
From PhosphataseWiki
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==== [[Phosphatase_Gene_DUSP26|DUSP26]] ==== | ==== [[Phosphatase_Gene_DUSP26|DUSP26]] ==== | ||
| − | + | DUSP26 (aka MKP8) is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma <cite>yangj10</cite>. | |
==== [[Phosphatase_Family_PPM#PPM1D|PPM1D]] ==== | ==== [[Phosphatase_Family_PPM#PPM1D|PPM1D]] ==== | ||
Revision as of 21:43, 2 June 2014
Contents
Cancer
DUSP26
DUSP26 (aka MKP8) is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma [1].
PPM1D
PPM1D as a frequent target of somatic mutation and as a potential therapeutic target in brainstem gliomas [2].
References
- Zhang L, Chen LH, Wan H, Yang R, Wang Z, Feng J, Yang S, Jones S, Wang S, Zhou W, Zhu H, Killela PJ, Zhang J, Wu Z, Li G, Hao S, Wang Y, Webb JB, Friedman HS, Friedman AH, McLendon RE, He Y, Reitman ZJ, Bigner DD, and Yan H. Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Nat Genet. 2014 Jul;46(7):726-30. DOI:10.1038/ng.2995 |
