Difference between revisions of "Phosphatases and Diseases"
From PhosphataseWiki
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==== [[Phosphatase_Gene_PTPRQ|PTPRQ]] and deafness ==== | ==== [[Phosphatase_Gene_PTPRQ|PTPRQ]] and deafness ==== | ||
See [http://omim.org/entry/603317 OMIM]. | See [http://omim.org/entry/603317 OMIM]. | ||
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| + | ==== [[Phosphatase_Gene_MTMR14|MTMR14]] and [http://en.wikipedia.org/wiki/Centronuclear_myopathy centronuclear myopathy] ==== | ||
| + | See [http://omim.org/entry/160150 OMIM]. | ||
== References == | == References == | ||
Revision as of 04:07, 6 June 2014
Contents
Cancer
PTEN
PTPN11 (SHP2)
PTPRC (CD45)
DUSP3 (VHR)
DUSP3 is a negative regulator of ERK and JNK pathways in in vitro studies in several cell lines. Though its role is involved in human cancer, its has contradictory roles since it has been alternatively described as having tumor suppressive and oncogenic properties [1].
DUSP26 (MKP8)
DUSP26 (aka MKP8) is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma [2].
PPM1D (WIP1)
PPM1D as a frequent target of somatic mutation and as a potential therapeutic target in brainstem gliomas [3].
Other diseases
PTPRQ and deafness
See OMIM.
MTMR14 and centronuclear myopathy
See OMIM.
References
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Error fetching PMID 20562916:
Error fetching PMID 24880341:
Error fetching PMID 20562916:
Error fetching PMID 24880341:
- Error fetching PMID 24886454:
- Error fetching PMID 20562916:
- Error fetching PMID 24880341:
