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| − | __NOTOC__
| + | ==Deprecated== |
| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
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| − | This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]].
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| − | The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Despite having only 15% sequence identity, human LMWPTP and SSU72 structures superimpose with an rmsd of 1.7 Å <cite>zhangy11</cite>.
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| − | A third family, arsenate reductase ([[Phosphatase_Family_ArsC|ArsC]]) <cite>Bennett</cite>, is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity. A different phosphatase fold, CDC25/Rhodanese also has members in plants and yeast (ACR2) that are capable of arsenate reductase activity, highlighting the similarity of the protein phosphatase and arsenate reductase activities.
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| − | == Reference == | + | |
| − | <biblio>
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| − | #zhangy11 pmid=21204787
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| − | #Bennett pmid=11698660
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| − | </biblio>
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