Difference between revisions of "Phosphatase Subfamily PTPRG"
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===Functions=== | ===Functions=== | ||
| − | + | The vertebrate forms are expressed in brain and involved in cell adhesion. Drosophila ptp99a is also selectively expressed and functions in the nervous system, interacting with other RPTPs, including Dlar and ptp69D. | |
===References=== | ===References=== | ||
Revision as of 04:53, 10 December 2014
Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily PTPRG
(Summary)
Evolution
PTPRG is found in eumetazoans, typically single-copy, but expanded to two genes, PTPRG and PTPRZ in human and other vertebrates.
Domain Structure
These are receptor PTPs with dual intracellular catalytic domains. The extracellular domain contains at least one FN3 domain. Vertebrate members have a catalytically inactive carbonic anhydrase (CA) domain, while most invertebrates, including one invertebrate chordate, have additional Ig and FN3 repeats instead. The CA domain acts as a receptor for members of the contactin family of neural cell adhesion molecules [1].
Functions
The vertebrate forms are expressed in brain and involved in cell adhesion. Drosophila ptp99a is also selectively expressed and functions in the nervous system, interacting with other RPTPs, including Dlar and ptp69D.
