Phosphatase Superfamily CC1

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Phosphatase classification: Fold CC1: Superfamily CC1

CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below:

  • PTP (Protein Tyrosine Phosphatase) - generally tyrosine-specific phosphatases.
  • DSP (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules.
  • PTEN - phosphoinositide phosphatases.
  • SAC - phosphoinositide phosphatases.
  • Paladin - catalytically inactive phosphatase.

Fungi, plants and many protists also have the OCA family.

CC1 shares a Cys-based catalytic motif, CX5R with another two superfamilies CC2 and CC3, but it has distinct structure from them.