Phosphatase Fold CC1

Phosphatase Classification: Fold CC1

Fold CC1 has a single superfamily CC1.

Structure

A structural alignment analysis of the crystal structures of five phosphatases of different families, including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses; Paladin and OCA have no structure). showed that all five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP [1]).

References

1. Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, and Møller NP. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol. 2001 Nov;21(21):7117-36. DOI:10.1128/MCB.21.21.7117-7136.2001 |