Difference between revisions of "Phosphatase Family PTEN"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]] |
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==== PTEN ==== | ==== PTEN ==== | ||
| − | ===== [[ | + | ===== [[Phosphatase_Subfamily_PTEN|PTEN subfamily]] ===== |
PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001193/overview unpublished data from gOrtholog]). | PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001193/overview unpublished data from gOrtholog]). | ||
| − | ===== [[ | + | ===== [[Phosphatase_Subfamily_VSP|VSP subfamily]] ===== |
The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication. | The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication. | ||
| − | ===== [[ | + | ===== [[Phosphatase_Subfamily_Tensin|Tensin subfamily]] ===== |
Tensin subfamily consists three tensins in human, TNS1, TNS3 and TENC1/TNS2. TNS4 is a distant relative but lacks a phosphatase domain. The subfamily is found in holozoa. | Tensin subfamily consists three tensins in human, TNS1, TNS3 and TENC1/TNS2. TNS4 is a distant relative but lacks a phosphatase domain. The subfamily is found in holozoa. | ||
| − | ===== [[ | + | ===== [[Phosphatase_Subfamily_Auxilin|Auxlin subfamily]] ===== |
Auxilin subfamily consists of two genes in human, [[Gene_DNAJC6|DNAJC6]] (Auxilin) and [[Gene_GAK|GAK]]. The subfamily is found mostly in metazoa. | Auxilin subfamily consists of two genes in human, [[Gene_DNAJC6|DNAJC6]] (Auxilin) and [[Gene_GAK|GAK]]. The subfamily is found mostly in metazoa. | ||
| − | === | + | === References === |
<biblio> | <biblio> | ||
#keyse06 pmid=17093265 | #keyse06 pmid=17093265 | ||
Revision as of 03:36, 28 December 2014
Phosphatase Classification: Superfamily CC1: Family PTEN
PTEN
PTEN subfamily
PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes (unpublished data from gOrtholog).
VSP subfamily
The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
Tensin subfamily
Tensin subfamily consists three tensins in human, TNS1, TNS3 and TENC1/TNS2. TNS4 is a distant relative but lacks a phosphatase domain. The subfamily is found in holozoa.
Auxlin subfamily
Auxilin subfamily consists of two genes in human, DNAJC6 (Auxilin) and GAK. The subfamily is found mostly in metazoa.
References
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Error fetching PMID 20720150:
- Error fetching PMID 17093265:
- Error fetching PMID 23847209:
- Error fetching PMID 20720150:
