Difference between revisions of "Phosphatase Fold AP"
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Fold AP (Alkaline phosphatase) has a single superfamily, [[Phosphatase_Superfamily_AP|AP]], which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear. | Fold AP (Alkaline phosphatase) has a single superfamily, [[Phosphatase_Superfamily_AP|AP]], which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear. | ||
Revision as of 20:59, 30 December 2014
Phosphatase Classification: Fold AP
Fold AP (Alkaline phosphatase) has a single superfamily, AP, which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: ALPI (alkaline phosphatase, intestinal), ALPP (alkaline phosphatase, placental), ALPPL2 (alkaline phosphatase, placental-like 2), and ALPL (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A [1, 2] and that PLAP is a protein tyrosine phosphatase [3], but their physiological relevance as protein phosphatases is still unclear.
Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold (SCOP), which contains other enzymes, such as phosphoesterases and sulfatases.
References
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