| − | The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and SSU72 families. Although human exhibits low sequence identity with proteins from any of the cysteine-based phosphatase family, except the existence of the PTP motif, the fold of the core domain is highly identical with that of LMWPTP (Figure 1E). A -CX5R- signature motif is located at the N-terminus of the protein. With the primary sequence consensus of only 15%, the overall fold of Ssu72 exhibits a Z score of 11.6 in a DALI search [36] and an rmsd (root mean square deviation) of 1.7 Å when superimposed with the main chain of LMWPTP (PDB code 1XWW) (Ssu72 6–195 excluding residues 41–96; LMWPTP 1–157 excluding residues 50–67).
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