Difference between revisions of "Phosphatase Subfamily CTDSPL2"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[ | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_CTDSPL2|CTDSPL2]] |
__NOTOC__ | __NOTOC__ | ||
| − | + | CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes. | |
| − | + | ||
| − | + | ||
| − | + | ||
===Evolution=== | ===Evolution=== | ||
| − | + | CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called HSPC058, HSPC129, or SCP4 | |
===Domain Structure=== | ===Domain Structure=== | ||
| − | + | Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension | |
===Catalytic activity=== | ===Catalytic activity=== | ||
| + | Human CTDSPL2 has experimentally-shown activity <cite>qian</cite> and orthologs are also predicted to be active. | ||
| + | ===Functions=== | ||
| + | Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway <cite>Zhao</cite> | ||
| − | === | + | ===Related Kinases=== |
| − | + | See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | |
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
#qian pmid=17487459 | #qian pmid=17487459 | ||
| + | #Zhao pmid=25100727 | ||
</biblio> | </biblio> | ||
===Links=== | ===Links=== | ||
| − | [http://www.ncbi.nlm.nih.gov/gene/51496 Human | + | [http://www.ncbi.nlm.nih.gov/gene/51496 Human CTDSPL2] from NCBI Gene |
Latest revision as of 01:02, 22 March 2017
Phosphatase Classification: FCP: CTDSPL2
CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.
Evolution
CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called HSPC058, HSPC129, or SCP4
Domain Structure
Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension
Catalytic activity
Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.
Functions
Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
- Qian H, Ji C, Zhao S, Chen J, Jiang M, Zhang Y, Yan M, Zheng D, Sun Y, Xie Y, and Mao Y. Expression and characterization of HSPC129, a RNA polymerase II C-terminal domain phosphatase. Mol Cell Biochem. 2007 Sep;303(1-2):183-8. DOI:10.1007/s11010-007-9472-z |
- Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, and Lin X. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26441-26450. DOI:10.1074/jbc.M114.568964 |
Links
Human CTDSPL2 from NCBI Gene
