Difference between revisions of "Phosphatase Subfamily PPP1C"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP1C|Subfamily PPP1C]] | + | __NOTOC__ |
| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]: [[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PPP|Family PPP]]: [[Phosphatase_Subfamily_PPP1C|Subfamily PPP1C]] (PP1) | ||
PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes. | PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes. | ||
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=== Functions === | === Functions === | ||
| − | The PPP1C subfamily is the catalytic subunit of PP1 holoenzyme binding to regulatory subunits to achieve diverse functions <cite>heroes13</cite>. Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes | + | The PPP1C subfamily is the catalytic subunit of PP1 holoenzyme binding to regulatory subunits to achieve diverse functions <cite>heroes13</cite>. Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes, such as cell cycle progression <cite>grallert14</cite> and glycogen metabolism. Below are some examples: |
PPP1C, in complex with regulatory subunits, dephosphorylates the substrates below: | PPP1C, in complex with regulatory subunits, dephosphorylates the substrates below: | ||
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* eIF2α. PPP1C-PPP1R15A holophosphatase in complex with G-actin, dephosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) and inhibits integrated stress response (ISR) <cite>Chambers15</cite>. | * eIF2α. PPP1C-PPP1R15A holophosphatase in complex with G-actin, dephosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) and inhibits integrated stress response (ISR) <cite>Chambers15</cite>. | ||
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| + | PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells <cite>Dessel15</cite>. | ||
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=== References === | === References === | ||
<biblio> | <biblio> | ||
#Chambers15 pmid=25774599 | #Chambers15 pmid=25774599 | ||
| + | #Dessel15 pmid=25907536 | ||
#grallert14 pmid=25487150 | #grallert14 pmid=25487150 | ||
#heroes13 pmid=22360570 | #heroes13 pmid=22360570 | ||
</biblio> | </biblio> | ||
Revision as of 20:39, 25 April 2015
Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PPP: Subfamily PPP1C (PP1)
PPP1C is a ubiquitous serine/threonine phosphatase found throughout eukaryotes and even in some prokaryotes. By forming complexes with different regulatory subunits, it is involved in many various processes.
Evolution
PPP1C subfamily is found throughout eukaryotes even in some prokaryotes. It has many lineage-specific gene duplications. In particular, 10 PPP1Cs are found in fruit fly, 3 in human, 3 in C. elegans, and 4 in yeast.
Domain
PPP1C has a single domain - phosphatase domain.
Functions
The PPP1C subfamily is the catalytic subunit of PP1 holoenzyme binding to regulatory subunits to achieve diverse functions [1]. Over 50 different regulatory subunits are known in human and at least 20 in yeast. These different complexes play key roles in various cellular processes, such as cell cycle progression [2] and glycogen metabolism. Below are some examples:
PPP1C, in complex with regulatory subunits, dephosphorylates the substrates below:
- Myosin (light chain). PPP1C forms myosin-light-chain phosphatase (MLCP) in complex with PPP1R12A (MYPT1/M130) and PPP1R12A (M20).
- eIF2α. PPP1C-PPP1R15A holophosphatase in complex with G-actin, dephosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) and inhibits integrated stress response (ISR) [3].
PPP1C, in complex with its regulatory subunit NIPP1, activates mesenchymal genes in HeLa cells [4].
References
Error fetching PMID 25907536:
Error fetching PMID 25487150:
Error fetching PMID 22360570:
- Error fetching PMID 22360570:
- Error fetching PMID 25487150:
- Error fetching PMID 25774599:
- Error fetching PMID 25907536:
