Difference between revisions of "Phosphatase Subfamily PPM1D"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1D|Subfamily PPM1D]] (WIP1) | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1D|Subfamily PPM1D]] (WIP1) | ||
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| + | === Evolution === | ||
| + | PPM1D (WIP1) most likely emerged in holozoa. It is single copy in most genomes, including human genome. See [http://resdev.gene.com/gOrtholog/view/cluster/MC0005181/overview internal gOrtholog database]. | ||
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| + | === Domain === | ||
| + | PPM1D (WIP1) has a single structure domain, the phosphatase domain of PPM (PP2C) fold. | ||
| + | |||
| + | === Function === | ||
| + | PPM1D is also known as WIP1 (Wild-type p53-induced phosphatase 1). It negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. It is therefore involved in diverse pathways. Below are some examples of its functions: | ||
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| + | PPM1D (WIP1) is highly expressed in HSCs but decreases with age, and WIP1-deficient (Wip1-/-) mice exhibited multifaceted HSC aging phenotypes, including the increased pool size and impaired repopulating activity <cite>Chen15</cite>. | ||
| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #Chen15 pmid=25879755 | ||
| + | </biblio> | ||
Revision as of 17:40, 17 April 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1D (WIP1)
Contents
Evolution
PPM1D (WIP1) most likely emerged in holozoa. It is single copy in most genomes, including human genome. See internal gOrtholog database.
Domain
PPM1D (WIP1) has a single structure domain, the phosphatase domain of PPM (PP2C) fold.
Function
PPM1D is also known as WIP1 (Wild-type p53-induced phosphatase 1). It negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. It is therefore involved in diverse pathways. Below are some examples of its functions:
PPM1D (WIP1) is highly expressed in HSCs but decreases with age, and WIP1-deficient (Wip1-/-) mice exhibited multifaceted HSC aging phenotypes, including the increased pool size and impaired repopulating activity [1].
