Difference between revisions of "Phosphatase Family LMWPTP"

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(Created page with "==Phosphatase Classification: LMWPTP== == Function == In eukaryotes, LMWPTP dephosphorylate many receptor tyrosi...")
 
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==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_LMWPTP|LMWPTP]]==
 
==[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_LMWPTP|LMWPTP]]==
 
  
 
== Function ==
 
== Function ==
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In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.
 
In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.
 
  
 
== Evolution ==
 
== Evolution ==
 
The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.  
 
The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.  
 
 
== Comparison of the catalytic site with LMW-PTP ==
 
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LMW-PTP
 
 
Ssu72
 
 
 
Sequence logo of catalytic site of Ssu72 and LMW-PTP. The logo of Ssu72 was built from 33 sequences, and that of LMW-PTP from 42 sequences including five known prokaryotic LMW-PTPs.
 
 
  
 
== Reference ==
 
== Reference ==

Revision as of 16:45, 30 April 2014

Phosphatase Classification: LMWPTP

Function

In eukaryotes, LMWPTP dephosphorylate many receptor tyrosine kianses, such as platelet-derived growth factor receptor (PDGFR), insulin receptor (InsR), or ephrin receptor (Eph) [1].

In prokaryotes, the molecular function is not fully understood. It is involved in the syntheisis and translocation of exopolysaccharides (EPS) and capsular polysaccharides (CPS) in E. coli.

Evolution

The LMWPTP is present not only in eukaryotes but also prokaryotes. In eukaryotes, it is generally absent from alveolates, trypanosoma, leishmania.

Reference

  1. Kikawa KD, Vidale DR, Van Etten RL, and Kinch MS. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. J Biol Chem. 2002 Oct 18;277(42):39274-9. DOI:10.1074/jbc.M207127200 | PubMed ID:12167657 | HubMed [Kikawa02]