Difference between revisions of "Phosphatase Subfamily PPM1K"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ) | + | __NOTOC__ |
| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP) | ||
=== Evolution === | === Evolution === | ||
| + | The PPM1K subfamily probably emerged in [[Phosphatase_Glossary#Holozoa|holozoa]]. It was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]] and sponge. Monosiga brevicollis PPM1K has accessory EF-hand domains at C-terminal. | ||
=== Domain === | === Domain === | ||
| + | The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain <cite>Joshi07, Lu07</cite>. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily. | ||
=== Functions === | === Functions === | ||
| − | + | Human PPM1K is widely expressed in different tissues, most abundant in heart as shown in <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>. | |
=== References === | === References === | ||
| + | <biblio> | ||
| + | #Joshi07 pmid=17336929 | ||
| + | #Lu07 pmid=17374715 | ||
| + | </biblio> | ||
Revision as of 19:14, 5 June 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1K (PP2Cκ, PP2Cm, BDP)
Evolution
The PPM1K subfamily probably emerged in holozoa. It was lost in ecdysozoa and sponge. Monosiga brevicollis PPM1K has accessory EF-hand domains at C-terminal.
Domain
The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain [1, 2]. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily.
Functions
Human PPM1K is widely expressed in different tissues, most abundant in heart as shown in [1, 2] and GTEx database. Human PPM1K is localized to mitochondrial matrix [2]. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear [2]. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex [1].
References
- Joshi M, Jeoung NH, Popov KM, and Harris RA. Identification of a novel PP2C-type mitochondrial phosphatase. Biochem Biophys Res Commun. 2007 Apr 27;356(1):38-44. DOI:10.1016/j.bbrc.2007.02.108 |
- Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, and Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. DOI:10.1101/gad.1499107 |
